Reduced acquisition time PET pharmacokinetic modelling using simultaneous ASL-MRI: proof of concept.

ABSTRACT: Pharmacokinetic modelling on dynamic positron emission tomography (PET) data is a quantitative technique. However, the long acquisition time is prohibitive for routine clinical use. Instead, the semi-quantitative standardised uptake value ratio (SUVR) from a shorter static acquisition is used, despite its sensitivity to blood flow confounding longitudinal analysis. A method has been proposed to reduce the dynamic acquisition time for quantification by incorporating cerebral blood flow (CBF) information from arterial spin labelling (ASL) magnetic resonance imaging (MRI) into the pharmacokinetic modelling. In this work, we optimise and validate this framework for a study of ageing and preclinical Alzheimer's disease. This methodology adapts the simplified reference tissue model (SRTM) for a

SUBMITTER: Scott CJ 

PROVIDER: S-EPMC6891000 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature