Cross-disorder analysis of schizophrenia and 19 immune-mediated diseases identifies shared genetic risk.

ABSTRACT: Many immune diseases occur at different rates among people with schizophrenia compared to the general population. Here, we evaluated whether this phenomenon might be explained by shared genetic risk factors. We used data from large genome-wide association studies to compare the genetic architecture of schizophrenia to 19 immune diseases. First, we evaluated the association with schizophrenia of 581 variants previously reported to be associated with immune diseases at genome-wide significance. We identified five variants with potentially pleiotropic effects. While colocalization analyses were inconclusive, functional characterization of these variants provided the strongest evidence for a model in which genetic variation at rs1734907 modulates risk of schizophrenia and Crohn's disease via a

SUBMITTER: Pouget JG 

PROVIDER: S-EPMC6891073 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature