Sleep disturbance and neurocognitive outcomes in older patients with breast cancer: Interaction with genotype.

ABSTRACT:

Background

Sleep disturbance and genetic profile are risks for cognitive decline in noncancer populations, yet their role in cancer-related cognitive problems remains understudied. This study examined whether sleep disturbance was associated with worse neurocognitive outcomes in breast cancer survivors and whether sleep effects on cognition varied by genotype.

Methods

Newly diagnosed female patients (n = 319) who were 60 years old or older and had stage 0 to III breast cancer were recruited from August 2010 to December 2015. Assessments were performed before systemic therapy and 12 and 24 months later. Neuropsychological testing measured attention, processing speed, executive function, learning, and memory; self-perceived cognitive functioning was also assessed. Sleep distur

SUBMITTER: Carroll JE 

PROVIDER: S-EPMC6891125 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature