Reward-Related Brain Activity Prospectively Predicts Increases in Alcohol Use in Adolescents.

ABSTRACT:

Objective

Altered activity within reward-related neural regions, including the ventral striatum (VS) and medial prefrontal cortex (mPFC), is associated with concurrent problematic substance use. The aims of the present study were (a) to identify patterns of reward-related neural activity that prospectively predicted changes in alcohol use 2 years after magnetic resonance imaging in a sample of adolescents, and (b) to examine whether these patterns differed by sex. We also tested whether depression symptoms or impulsivity mediated associations between neural activity and future alcohol use.

Method

Participants were 262 adolescents (129 male and 133 female) of Mexican origin who completed the Monetary Incentive Delay task during a functional magnetic resonance imaging scan at

SUBMITTER: Swartz JR 

PROVIDER: S-EPMC6891148 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature