Postdiagnosis Loss of Skeletal Muscle, but Not Adipose Tissue, Is Associated with Shorter Survival of Patients with Advanced Pancreatic Cancer.

ABSTRACT:

Background

Pancreatic cancer is associated with development of cachexia, a wasting syndrome thought to limit survival. Few studies have longitudinally quantified peripheral tissues or identified biomarkers predictive of future tissue wasting.

Methods

Adipose and muscle tissue were measured by computed tomography (CT) at diagnosis and 50 to 120 days later in 164 patients with advanced pancreatic cancer. Tissue changes and survival were evaluated by Cox proportional hazards regression. Baseline levels of circulating markers were examined in relation to future tissue wasting.

Results

Compared with patients in the bottom quartile of muscle change per 30 days (average gain of 0.8 ± 2.0 cm²), those in the top quartile (average loss of 12.9 ± 4.9 cm²) h

SUBMITTER: Babic A 

PROVIDER: S-EPMC6891169 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature