Cys34 Adductomics Links Colorectal Cancer with the Gut Microbiota and Redox Biology.

ABSTRACT: Chronic inflammation is an established risk factor for colorectal cancer. To study reactive products of gut inflammation and redox signaling on colorectal cancer development, we used untargeted adductomics to detect adduct features in prediagnostic serum from the EPIC Italy cohort. We focused on modifications to Cys34 in human serum albumin, which is responsible for scavenging small reactive electrophiles that might initiate cancers. Employing a combination of statistical methods, we selected seven Cys34 adducts associated with colorectal cancer, as well as body mass index (BMI; a well-known risk factor). Five adducts were more abundant in colorectal cancer cases than controls and clustered with each other, suggesting a common pathway. Because two of these adducts were Cys34 modifications

SUBMITTER: Grigoryan H 

PROVIDER: S-EPMC6891211 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature