Hydrogen peroxide depolarizes mitochondria and inhibits IP₃-evoked Ca²⁺ release in the endothelium of intact arteries.

ABSTRACT: Hydrogen peroxide (H₂O₂) is a mitochondrial-derived reactive oxygen species (ROS) that regulates vascular signalling transduction, vasocontraction and vasodilation. Although the physiological role of ROS in endothelial cells is acknowledged, the mechanisms underlying H₂O₂ regulation of signalling in native, fully-differentiated endothelial cells is unresolved. In the present study, the effects of H₂O₂ on Ca²⁺ signalling were investigated in the endothelium of intact rat mesenteric arteries. Spontaneous local Ca²⁺ signals and acetylcholine evoked Ca²⁺ increases were inhibited by H₂O₂. H₂O₂ inhibition of acetylcholine-evoked Ca²⁺ signals wa

SUBMITTER: Zhang X 

PROVIDER: S-EPMC6891240 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature