Basal ganglia volume and shape in anorexia nervosa.

ABSTRACT:

Background

Reward-centred models have proposed that anomalies in the basal ganglia circuitry that underlies reward learning and habit formation perpetuate anorexia nervosa (AN). The present study aimed to investigate the volume and shape of key basal ganglia regions, including the bilateral caudate, putamen, nucleus accumbens (NAcc), and globus pallidus in AN.

Methods

The present study combined data from two existing studies resulting in a sample size of 46 women with AN and 56 age-matched healthy comparison (HC) women. Group differences in volume and shape of the regions of interest were examined. Within the AN group, the impact of eating disorder characteristics on volume and shape of the basal ganglia regions were also explored.

Results

The shape analyses revealed

SUBMITTER: Leppanen J 

PROVIDER: S-EPMC6891247 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature