Predicting drug-free remission in rheumatoid arthritis: A prospective interventional cohort study.

ABSTRACT:

Background

Many patients with rheumatoid arthritis (RA) achieve disease remission with modern treatment strategies. However, having achieved this state, there are no tests that predict when withdrawal of therapy will result in drug-free remission rather than flare. We aimed to identify predictors of drug-free remission in RA.

Methods

The Biomarkers of Remission in Rheumatoid Arthritis (BioRRA) Study was a unique, prospective, interventional cohort study of complete and abrupt cessation of conventional synthetic disease-modifying anti-rheumatic drugs (DMARDs). Patients with RA of at least 12 months duration and in clinical and ultrasound remission discontinued DMARDs and were monitored for six months. The primary outcome was time-to-flare, defined as disease activity score in

SUBMITTER: Baker KF 

PROVIDER: S-EPMC6891251 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature