Proteomic Characterization of High-Density Lipoprotein Particles from Non-Diabetic Hemodialysis Patients.

ABSTRACT: Chronic kidney disease is associated with an increased cardiovascular risk, and altered biological properties of high-density lipoproteins (HDL) may play a role in these events. This study aimed to describe the HDL proteome from non-diabetic hemodialysis patients and identify potential pathways affected by the dysregulated expression of HDL proteins. HDL were sampled from nine non-diabetic hemodialysis (HD) and eight control patients. Samples were analyzed using a nano-RSLC coupled with a Q-Orbitrap. Data were processed by database searching using SequestHT against a human Swissprot database and quantified with a label-free quantification approach. Proteins that were in at least five of the eight control and six of the nine HD patients were analyzed. Analysis was based on pairwise ratios a

SUBMITTER: Florens N 

PROVIDER: S-EPMC6891510 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature