Identifying Promiscuous Compounds with Activity against Different Target Classes.

ABSTRACT: Compounds with multitarget activity are of high interest for polypharmacological drug discovery. Such promiscuous compounds might be active against closely related target proteins from the same family or against distantly related or unrelated targets. Compounds with activity against distinct targets are not only of interest for polypharmacology but also to better understand how small molecules might form specific interactions in different binding site environments. We have aimed to identify compounds with activity against drug targets from different classes. To these ends, a systematic analysis of public biological screening data was carried out. Care was taken to exclude compounds from further consideration that were prone to experimental artifacts and false positive activity readouts. Ex

SUBMITTER: Feldmann C 

PROVIDER: S-EPMC6891533 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature