Curcumin Derivatives Verify the Essentiality of ROS Upregulation in Tumor Suppression.

ABSTRACT:

Background

Curcumin has been shown to exert pleiotropic biological effects, including anti-tumorigenic activity. We previously showed that curcumin controls reactive oxygen species (ROS) levels through the ROS metabolic enzymes, to prevent tumor cell growth. In this study, we synthesized 39 novel curcumin derivatives and examined their anti-proliferative and anti-tumorigenic properties.

Methods and results

Thirty-nine derivatives exhibited anti-proliferative activity toward human cancer cell lines, including CML-derived K562 leukemic cells, in a manner sensitive to an antioxidant, N-acetyl-cysteine (NAC). Some compounds exhibited lower GI₅₀ values than curcumin, some efficiently induced cell senescence, and others markedly increased ROS levels, efficiently

SUBMITTER: Nakamae I 

PROVIDER: S-EPMC6891586 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature