Ontology highlight
ABSTRACT:
SUBMITTER: Jodal L
PROVIDER: S-EPMC6891593 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Jødal Lars L Roivainen Anne A Oikonen Vesa V Jalkanen Sirpa S Hansen Søren B SB Afzelius Pia P Alstrup Aage K O AKO Nielsen Ole L OL Jensen Svend B SB
Molecules (Basel, Switzerland) 20191113 22
<h4>Background</h4>[<sup>68</sup>Ga]Ga-DOTA-Siglec-9 is a positron emission tomography (PET) radioligand for vascular adhesion protein 1 (VAP-1), a protein involved in leukocyte trafficking. The tracer facilitates the imaging of inflammation and infection. Here, we studied the pharmacokinetic modelling of [<sup>68</sup>Ga]Ga-DOTA-Siglec-9 in osteomyelitis and soft tissue infections in pigs.<h4>Methods</h4>Eight pigs with osteomyelitis and soft tissue infections in the right hind limb were dynami ...[more]