NAD Analogs in Aid of Chemical Biology and Medicinal Chemistry.

ABSTRACT: Nicotinamide adenine dinucleotide (NAD) serves as an essential redox co-factor and mediator of multiple biological processes. Besides its well-established role in electron transfer reactions, NAD serves as a substrate for other biotransformations, which, at the molecular level, can be classified as protein post-translational modifications (protein deacylation, mono-, and polyADP-ribosylation) and formation of signaling molecules (e.g., cyclic ADP ribose). These biochemical reactions control many crucial biological processes, such as cellular signaling and recognition, DNA repair and epigenetic modifications, stress response, immune response, aging and senescence, and many others. However, the links between the biological effects and underlying molecular processes are often poorly understoo

SUBMITTER: Depaix A 

PROVIDER: S-EPMC6891637 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature