Novel PDMS-Based Sensor System for MPWM Measurements of Picoliter Volumes in Microfluidic Devices.

ABSTRACT: In order for automatic microinjection to serve biomedical and genetic research, we have designed and manufactured a PDMS-based sensor with a circular section channel using the microwire molding technique. For the very precise control of microfluidic transport, we developed a microfluidic pulse width modulation system (MPWM) for automatic microinjections at a picoliter level. By adding a computer-aided detection and tracking of fluid-specific elements in the microfluidic circuit, the PDMS microchannel sensor became the basic element in the automatic control of the microinjection sensor. With the PDMS microinjection sensor, we precise measured microfluidic volumes under visual detection, assisted by very precise computer equipment (with precision below 1 μm) based on image processing. The ca

SUBMITTER: Ardeleanu MN 

PROVIDER: S-EPMC6891790 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature