The effect of remote ischaemic preconditioning on myocardial injury in emergency hip fracture surgery (PIXIE trial): phase II randomised clinical trial.

ABSTRACT:

Objective

To investigate whether remote ischaemic preconditioning (RIPC) prevents myocardial injury in patients undergoing hip fracture surgery.

Design

Phase II, multicentre, randomised, observer blinded, clinical trial.

Setting

Three Danish university hospitals, 2015-17.

Participants

648 patients with cardiovascular risk factors undergoing hip fracture surgery. 286 patients were assigned to RIPC and 287 were assigned to standard practice (control group).

Intervention

The RIPC procedure was initiated before surgery with a tourniquet applied to the upper arm and consisted of four cycles of forearm ischaemia for five minutes followed by reperfusion for five minutes.

Main outcome measures

The original primary outcome was myocardial injury within four

SUBMITTER: Ekeloef S 

PROVIDER: S-EPMC6891801 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature