Transient receptor potential melastatin 2 channels are overexpressed in myalgic encephalomyelitis/chronic fatigue syndrome patients.

ABSTRACT:

Background

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is hallmarked by a significant reduction in natural killer (NK) cell cytotoxicity, a mechanism tightly regulated by calcium (Ca²⁺). Interestingly, interleukin-2 (IL-2) increases NK cell cytotoxicity. Transient receptor potential melastatin 2 (TRPM2) ion channels are fundamental for Ca²⁺ signalling in NK cells. This pilot investigation aimed to characterise TRPM2 and CD38 surface expression in vitro on NK cells in ME/CFS patients. This investigation furthermore examined the pharmaceutical effect of 8-bromoadenosine phosphoribose (8-Br-ADPR) and N₆-Benzoyladenosine-3',5'-cyclic monophosphate (N₆-Bnz-cAMP) on TRPM2 and CD38 surface expression and NK cell cytotoxicity betw

SUBMITTER: Balinas C 

PROVIDER: S-EPMC6891975 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature