Folate receptor-targeted positron emission tomography of experimental autoimmune encephalomyelitis in rats.

ABSTRACT:

Background

Folate receptor-β (FR-β) is a cell surface receptor that is significantly upregulated on activated macrophages during inflammation and provides a potential target for folate-based therapeutic and diagnostic agents. FR-β expression in central nervous system inflammation remains relatively unexplored. Therefore, we used focally induced acute and chronic phases of experimental autoimmune encephalomyelitis (EAE) to study patterns of FR-β expression and evaluated its potential as an in vivo imaging target.

Methods

Focal EAE was induced in rats using heat-killed Bacillus Calmette-Guérin followed by activation with complete Freund's adjuvant supplemented with Mycobacterium tuberculosis. The rats were assessed with magnetic resonance imaging and positron emission tomograp

SUBMITTER: Elo P 

PROVIDER: S-EPMC6892159 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature