Dysregulation of MicroRNA Regulatory Network in Lower Extremities Arterial Disease.

ABSTRACT: Atherosclerosis and its comorbidities are the major contributors to the global burden of death worldwide. Lower extremities arterial disease (LEAD) is a common manifestation of atherosclerotic disease of arteries of lower extremities. MicroRNAs belong to epigenetic factors that regulate gene expression and have not yet been extensively studied in LEAD. We aimed to indicate the most promising microRNA and gene expression signatures of LEAD, to identify interactions between microRNA and genes and to describe potential effect of modulated gene expression. High-throughput sequencing was employed to examine microRNAome and transcriptome of peripheral blood mononuclear cells of patients with LEAD, in relation to controls. Statistical significance of microRNAs and genes analysis results was evalu

SUBMITTER: Bogucka-Kocka A 

PROVIDER: S-EPMC6892359 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature