Retinal Layer Thicknesses in Early Age-Related Macular Degeneration: Results From the German AugUR Study.

ABSTRACT:

Purpose

To systematically analyze thicknesses of retinal layers in an older population and their link to early age-related macular degeneration (AMD).

Methods

In the AugUR baseline survey from a population aged ≥70 years, we conducted multimodal retinal imaging, including spectral-domain optical coherence tomography. Autosegmentation of eight distinct retinal layers was followed by manual correction of segmentation errors. AMD status was graded on color fundus images according to the Three Continent AMD Consortium Severity Scale. We tested the association of early AMD on retinal layer thicknesses by using linear mixed models and replicated significant results in independent data also from the AugUR platform.

Results

When comparing layer thicknesses between early AMD a

SUBMITTER: Brandl C 

PROVIDER: S-EPMC6892378 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature