Magnetoencephalography imaging of high frequency oscillations strengthens presurgical localization and outcome prediction.

ABSTRACT: In patients with medically refractory epilepsy, resective surgery is the mainstay of therapy to achieve seizure freedom. However, ∼20-50% of cases have intractable seizures post-surgery due to the imprecise determination of epileptogenic zone. Recent intracranial studies suggest that high frequency oscillations between 80 and 200 Hz could serve as one of the consistent epileptogenicity biomarkers for localization of the epileptogenic zone. However, these high frequency oscillations are not adopted in the clinical setting because of difficult non-invasive detection. Here, we investigated non-invasive detection and localization of high frequency oscillations and its clinical utility in accurate pre-surgical assessment and post-surgical outcome prediction. We prospectively recruited 52 patien

SUBMITTER: Velmurugan J 

PROVIDER: S-EPMC6892422 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature