Microwave-assisted, rapid synthesis of 2-vinylquinolines and evaluation of their antimalarial activity.

ABSTRACT: A rapid and efficient synthesis of 2-vinylquinolines via trifluoromethanesulfonamidemediated olefination of 2-methylquinoline and aldehyde under microwave irradiation is reported. Biological evaluation of these scaffolds demonstrates that 2-vinylquinolines 3x - 3z possess excellent antimalarial activities against chloroquine-resistant Dd2 strain of Plasmodium falciparum (IC50 < 100 nM).

SUBMITTER: Huang G 

PROVIDER: S-EPMC6892474 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature