Cardiac metabolomic profile of the naked mole-rat-glycogen to the rescue.

ABSTRACT: The African naked mole-rat (Heterocephalus glaber) is unique among mammals, displaying extreme longevity, resistance to cardiovascular disease and an ability to survive long periods of extreme hypoxia. The metabolic adaptations required for resistance to hypoxia are hotly debated and a recent report provides evidence that they are able to switch from glucose to fructose driven glycolysis in the brain. However, other systemic alterations in their metabolism are largely unknown. In the current study, a semi-targeted high resolution ¹H magnetic resonance spectroscopy (MRS) metabolomics investigation was performed on cardiac tissue from the naked mole-rat (NMR) and wild-type C57/BL6 mice to better understand these adaptations. A range of metabolic differences was observed in

SUBMITTER: Faulkes CG 

PROVIDER: S-EPMC6892520 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature