Nucleotide composition affects codon usage toward the 3'-end.

ABSTRACT: The 3'-end of the coding sequence in several species is known to show specific codon usage bias. Several factors have been suggested to underlie this phenomenon, including selection against translation efficiency, selection for translation accuracy, and selection against RNA folding. All are supported by some evidence, but there is no general agreement as to which factors are the main determinants. Nor is it known how universal this phenomenon is, and whether the same factors explain it in different species. To answer these questions, we developed a measure that quantifies the codon usage bias at the gene end, and used it to compute this bias for 91 species that span the three domains of life. In addition, we characterized the codons in each species by features that allow discrimination be

SUBMITTER: Zahdeh F 

PROVIDER: S-EPMC6892556 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature