Interhemispherically dynamic representation of an eye movement-related activity in mouse frontal cortex.

ABSTRACT: Cortical plasticity is fundamental to motor recovery following cortical perturbation. However, it is still unclear how this plasticity is induced at a functional circuit level. Here, we investigated motor recovery and underlying neural plasticity upon optogenetic suppression of a cortical area for eye movement. Using a visually-guided eye movement task in mice, we suppressed a portion of the secondary motor cortex (MOs) that encodes contraversive eye movement. Optogenetic unilateral suppression severely impaired contraversive movement on the first day. However, on subsequent days the suppression became inefficient and capability for the movement was restored. Longitudinal two-photon calcium imaging revealed that the regained capability was accompanied by an increased number of neurons enco

SUBMITTER: Sato TR 

PROVIDER: S-EPMC6892611 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature