Physiologic intestinal ¹⁸F-FDG uptake is associated with alteration of gut microbiota and proinflammatory cytokine levels in breast cancer.

ABSTRACT: The clinical significance of physiologic Fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) intestinal uptake (IU) based on the predicted link with gut microbiota dysbiosis and inflammatory cytokine production was investigated in a cohort of breast cancer patients. A total of 114 patients were visually classified into the lower or higher IU group. The maximum and mean standardized uptake values of total bowel (TB SUV_max and TB SUV_mean) were measured. The gut microbial abundance of the Citrobacter genus of the Enterobacteriaceae family showed a significant positive correlation with TB SUV_max and TB SUV_mean (q = 0.021 and q = 0.010). The unclassified Ruminococcaceae showed a significant negative correlation with TB SUV_max (q = 0.010). T

SUBMITTER: Yoon HJ 

PROVIDER: S-EPMC6892830 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature