GWAS studies reveal a possible genetic link between cancer and suicide attempt.

ABSTRACT: Inuit is the population with the highest incidence of suicide attempt and cancer in the world. Previous studies reported that people attempted suicide have a higher future risk for cancer. In view of these data, the largest available genome wide association studies (GWAS) for four major mental disorder groups were screened here for any common genes with all known cancer associated genes and oncogenes/tumor suppressor genes. A common genetic background came out only between suicide attempt and cancer (cancer associated genes analysis: RR = 1.64, p = 7.83 × 10^-5; oncogenes/tumor suppressor genes analysis: RR = 2.55, p = 2.82 × 10^-22), this supporting existing epidemiological data. Incidence/prevalence of both conditions was found to correlate with extreme cold geographi

SUBMITTER: Voskarides K 

PROVIDER: S-EPMC6892859 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature