Pu-Erh Tea Relaxes the Thoracic Aorta of Rats by Reducing Intracellular Calcium.

ABSTRACT: Previous studies suggested that pu-erh tea aqueous extract could lower blood pressure and ameliorate hypertension symptoms. However, the antihypertension mechanisms of pu-erh tea remain unclear. In this work, the direct effects of pu-erh tea on vessels and cells were investigated by detecting isometric tension and intracellular calcium ([Ca²⁺]_i), respectively. Additionally, to identify the main active components, the aqueous extract of pu-erh was separated by organic solvents to obtain various fractions, and the effects of these fractions on arteries were assessed. The results showed that pu-erh aqueous extract vasodilated rat thoracic aortas preconstricted by phenylephrine or KCl. These vasodilation effects were not significantly affected by the removal of the endoth

SUBMITTER: Luo D 

PROVIDER: S-EPMC6892945 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature