Pulmonary Exposure to Magneli Phase Titanium Suboxides Results in Significant Macrophage Abnormalities and Decreased Lung Function.

ABSTRACT: Coal is one of the most abundant and economic sources for global energy production. However, the burning of coal is widely recognized as a significant contributor to atmospheric particulate matter linked to deleterious respiratory impacts. Recently, we have discovered that burning coal generates large quantities of otherwise rare Magnéli phase titanium suboxides from TiO₂ minerals naturally present in coal. These nanoscale Magnéli phases are biologically active without photostimulation and toxic to airway epithelial cells in vitro and to zebrafish in vivo. Here, we sought to determine the clinical and physiological impact of pulmonary exposure to Magnéli phases using mice as mammalian model organisms. Mice were exposed to the most frequently found Magnéli phases, T

SUBMITTER: McDaniel DK 

PROVIDER: S-EPMC6892980 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature