RAACBook: a web server of reduced amino acid alphabet for sequence-dependent inference by using Chou's five-step rule.

ABSTRACT: By reducing amino acid alphabet, the protein complexity can be significantly simplified, which could improve computational efficiency, decrease information redundancy and reduce chance of overfitting. Although some reduced alphabets have been proposed, different classification rules could produce distinctive results for protein sequence analysis. Thus, it is urgent to construct a systematical frame for reduced alphabets. In this work, we constructed a comprehensive web server called RAACBook for protein sequence analysis and machine learning application by integrating reduction alphabets. The web server contains three parts: (i) 74 types of reduced amino acid alphabet were manually extracted to generate 673 reduced amino acid clusters (RAACs) for dealing with unique protein problems. It is

SUBMITTER: Zheng L 

PROVIDER: S-EPMC6893003 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature