The interplay between Epstein-Bar virus (EBV) with the p53 and its homologs during EBV associated malignancies.

ABSTRACT: p53, p63, and p73, the members of the p53 family of proteins, are structurally similar proteins that play central roles regulating cell cycle and apoptotic cell death. Alternative splicing at the carboxyl terminus and the utilization of different promoters further categorizes these proteins as having different isoforms for each. Among such isoforms, TA and ΔN versions of each protein serve as the pro and the anti-apoptotic proteins, respectively. Changes in the expression patterns of these isoforms are noted in many human cancers. Proteins of certain human herpesviruses, like Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV), interact with p53 family members and alter their expressions in many malignancies. Upon infections in the B cells and epithelial cells, EBV

SUBMITTER: Chatterjee K 

PROVIDER: S-EPMC6893087 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature