Acute Rodent Tolerability, Toxicity, and Radiation Dosimetry Estimates of the S1P1-Specific Radioligand [¹¹C]CS1P1.

ABSTRACT:

Purpose

In preclinical studies with rodent models of inflammatory diseases, [¹¹C]CS1P1 has been identified as a promising imaging agent targeting sphingosine-1-phosphate receptor 1 (S1P1) in the central nervous system and other tissues. In preparation for USA Food and Drug Administration (FDA) approval of [¹¹C]CS1P1 for human use, an acute biodistribution study in mice and an acute tolerability and toxicity evaluation in rats were conducted.

Procedures

Acute organ biodistribution and excretion data was obtained using male and female Swiss Webster mice intravenously (IV) injected with 4.8-10 MBq of [¹¹C]CS1P1. The organ residence times for each harvested organ were calculated using the animal biodistribution data, and were entered in the progr

SUBMITTER: Liu H 

PROVIDER: S-EPMC6893109 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature