A toxicological study on photo-degradation products of environmental ibuprofen: Ecological and human health implications.

ABSTRACT: Increasing quantities of pharmaceutical waste in the environment have disrupted the balance of ecosystems, and may have subsequent effects on human health. Although a handful of previous studies have shown the impacts of pharmaceutically active compounds on the environment, the toxicological effects of their degradation products remain largely unknown. In the current study, the photo-degradation products of environmental ibuprofen were assessed for both ecotoxicological and human health effects using a series of in vitro assays. Here, six of the major degradation products are synthesized with high purity (>98%) and characterized with ¹HNMR, ¹³CNMR, FT-IR and HRMS. To evaluate human health effects, three gut microbiota species, Lactobacillus acidophilus, Enterococcus f

SUBMITTER: Ellepola N 

PROVIDER: S-EPMC6893141 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature