Corosolic acid ameliorates cardiac hypertrophy via regulating autophagy.

ABSTRACT: In this work, we explored the role of corosolic acid (CRA) during pressure overload-induced cardiac hypertrophy. Cardiac hypertrophy was induced in mice by aortic banding. Four weeks post-surgery, CRA-treated mice developed blunted cardiac hypertrophy, fibrosis, and dysfunction, and showed increased LC3 II and p-AMPK expression. In line with the in vivo studies, CRA also inhibited the hypertrophic response induced by PE stimulation accompanying with increased LC3 II and p-AMPK expression. It was also found that CRA blunted cardiomyocyte hypertrophy and promoted autophagy in Angiotensin II (Ang II)-treated H9c2 cells. Moreover, to further verify whether CRA inhibits cardiac hypertrophy by the activation of autophagy, blockade of autophagy was achieved by CQ (an inhibitor of the fusion betwe

SUBMITTER: Wang ZP 

PROVIDER: S-EPMC6893168 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature