rmtA-Dependent Transcriptome and Its Role in Secondary Metabolism, Environmental Stress, and Virulence in Aspergillus flavus.

ABSTRACT: Aspergillus flavus colonizes numerous oil seed crops such as maize, peanuts, treenuts and cottonseed worldwide, contaminating them with aflatoxins and other harmful toxins. Previously our lab characterized the gene rmtA, which encodes an arginine methyltransferase in A. flavus, and demonstrated its role governing the expression of regulators in the aflatoxin gene cluster and subsequent synthesis of toxin. Furthermore, our studies revealed that rmtA also controls conidial and sclerotial development implicating it as an epigenetic regulator in A. flavus To confirm this, we performed a RNA sequencing analysis to ascertain the extent of rmtA's influence on the transcriptome of A. flavus In this analysis we identified over 2000 genes that were

SUBMITTER: Satterlee T 

PROVIDER: S-EPMC6893206 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature