Sex-specific Associations Between Serum Hemoglobin Levels and the Risk of Cause-specific Death in Korea Using the National Health Insurance Service-National Health Screening Cohort (NHIS HEALS).

ABSTRACT:

Objectives

The purpose of this study was to determine the associations between blood hemoglobin (Hgb) levels and the risk of death by specific causes.

Methods

Using the National Health Insurance Services-National Health Screening Cohort (n=487 643), we classified serum Hgb levels into 6 sex-specific groups. Cox regression analysis was used to analyze the associations between Hgb levels and the risk of cause-specific death.

Results

Hgb levels in male population showed a U-shaped, J-shaped, or inverse J-shaped association with the risk of death from ischemic heart disease, acute myocardial infarction, liver cancer, cirrhosis and chronic obstructive pulmonary disease (COPD) (all non-linear p<0.05; hazard ratio [HR]; 95% confidence interval [CI]) for the lowest and the

SUBMITTER: An Y 

PROVIDER: S-EPMC6893230 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature