Nanoparticle-Based Contrast Agents for 129Xe HyperCEST NMR and MRI Applications.

ABSTRACT: Spin hyperpolarization techniques have enabled important advancements in preclinical and clinical MRI applications to overcome the intrinsic low sensitivity of nuclear magnetic resonance. Functionalized xenon biosensors represent one of these approaches. They combine two amplification strategies, namely, spin exchange optical pumping (SEOP) and chemical exchange saturation transfer (CEST). The latter one requires host structures that reversibly bind the hyperpolarized noble gas. Different nanoparticle approaches have been implemented and have enabled molecular MRI with 129Xe at unprecedented sensitivity. This review gives an overview of the Xe biosensor concept, particularly how different nanoparticles address various critical aspects of gas binding and exchange, spectral dispersion for mu

SUBMITTER: Jayapaul J 

PROVIDER: S-EPMC6893250 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature