Programmed Cell Death in Neurospora crassa Is Controlled by the Allorecognition Determinant rcd-1.

ABSTRACT: Nonself recognition following cell fusion between genetically distinct individuals of the same species in filamentous fungi often results in a programmed cell death (PCD) reaction, where the heterokaryotic fusion cell is compartmentalized and rapidly killed. The allorecognition process plays a key role as a defense mechanism that restricts genome exploitation, resource plundering, and the spread of deleterious senescence plasmids and mycoviruses. Although a number of incompatibility systems have been described that function in mature hyphae, less is known about the PCD pathways in asexual spores, which represent the main infectious unit in various human and plant fungal pathogens. Here, we report the identification of regulator of cell death-1 (rcd-1), a novel allorecognition

SUBMITTER: Daskalov A 

PROVIDER: S-EPMC6893366 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature