mastermind regulates niche ageing independently of the Notch pathway in the Drosophila ovary.

ABSTRACT: Proper stem cell activity in tissues ensures the correct balance between proliferation and differentiation, thus allowing tissue homeostasis and repair. The Drosophila ovary develops well-defined niches that contain on average 2-4 germline stem cells (GSCs), whose maintenance depends on systemic signals and local factors. A known player in the decline of tissue homeostasis is ageing, which correlates with the waning of resident stem cell populations. In Drosophila, ovaries from old females contain fewer GSCs than those from young flies. We isolated niche cells of aged ovaries, performed a transcriptomic analysis and identified mastermind (mam) as a factor for Drosophila ovarian niche functionality during ageing. We show that mam is upregulated in aged nic

SUBMITTER: Lobo-Pecellin M 

PROVIDER: S-EPMC6893403 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature