Impact of Donor Human Milk in the Preterm Very Low Birth Weight Gut Transcriptome Profile by Use of Exfoliated Intestinal Cells.

ABSTRACT: Own mother's milk (OMM) is the optimal nutrition for preterm infants. However, pasteurized donor human milk (DHM) is a valid alternative. We explored the differences of the transcriptome in exfoliated epithelial intestinal cells (EEIC) of preterm infants receiving full feed with OMM or DHM. The prospective observational study included preterm infants ≤ 32 weeks' gestation and/or ≤1500 g birthweight. Total RNA from EEIC were processed for genome-wide expression analysis. Principal component analysis and unsupervised hierarchical clustering analysis revealed two clustered groups corresponding to the OMM and DHM groups that showed differences in the gene expression profile in 1629 transcripts. The OMM group overexpressed lactalbumin alpha gene (LALBA), Cytochrome C oxidase subunit I gene (COX

SUBMITTER: Parra-Llorca A 

PROVIDER: S-EPMC6893464 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature