Evolution of a Landscape Phage Library in a Mouse Xenograft Model of Human Breast Cancer.

ABSTRACT: Peptide-displayed phage libraries are billion-clone collections of diverse chimeric bacteriophage particles, decorated by genetically fused peptides built from a random combination of natural amino acids. Studying the molecular evolution of peptide-displayed libraries in mammalian model systems, using in vivo phage display techniques, can provide invaluable knowledge about the underlying physiology of the vasculature system, allow recognition of organ- and tissue-specific networks of protein-protein interactions, and provide ligands for targeted diagnostics and therapeutics. Recently, we discovered that landscape phage libraries, a specific type of multivalent peptide phage display library, expose on their surface comprehensive collections of elementary binding units (EBUs), which can form

SUBMITTER: Gillespie JW 

PROVIDER: S-EPMC6893515 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature