Butyric Acid and Leucine Induce α-Defensin Secretion from Small Intestinal Paneth Cells.

ABSTRACT: The intestine not only plays a role in fundamental processes in digestion and nutrient absorption, but it also has a role in eliminating ingested pathogenic bacteria and viruses. Paneth cells, which reside at the base of small intestinal crypts, secrete α-defensins and contribute to enteric innate immunity through potent microbicidal activities. However, the relationship between food factors and the innate immune functions of Paneth cells remains unknown. Here, we examined whether short-chain fatty acids and amino acids induce α-defensin secretion from Paneth cells in the isolated crypts of small intestine. Butyric acid and leucine elicit α-defensin secretion by Paneth cells, which kills Salmonella typhimurium. We further measured Paneth cell secretion in response to butyric acid and leuci

SUBMITTER: Takakuwa A 

PROVIDER: S-EPMC6893607 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature