Survivin Overexpression Has a Negative Effect on Feline Calicivirus Infection.

ABSTRACT: It is known that levels of the anti-apoptotic protein survivin are reduced during Murine norovirus MNV-1 and Feline calicivirus (FCV) infection as part of the apoptosis establishment required for virus release and propagation in the host. Recently, our group has reported that overexpression of survivin causes a reduction of FCV protein synthesis and viral progeny production, suggesting that survivin may affect early steps of the replicative cycle. Using immunofluorescence assays, we observed that overexpression of survivin, resulted in the reduction of FCV infection not only in transfected but also in the neighboring nontransfected CrFK cells, thus suggesting autocrine and paracrine protective effects. Cells treated with the supernatants collected from CrFK cells overexpressing survivin sh

SUBMITTER: Barrera-Vazquez OS 

PROVIDER: S-EPMC6893618 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature