Is There a Contribution of Structural Brain Phenotypes to the Variance in Resting Energy Expenditure before and after Weight Loss in Overweight Females?

ABSTRACT: Brain gray (GM) and white matter (WM) are associated with resting energy expenditure (REE). The impact of weight loss on GM and WM masses, as well as on their associations with REE and the ratio between body and brain metabolism, i.e., encephalic measure (EM)), are unknown. Longitudinal data of 69 female Caucasian subjects (age range 19-69 years) with detailed information on fat mass (FM), fat free mas (FFM), GM, WM and REE. Mean weight loss was 14.5 ± 11.9 kg with changes in FM (-12.9 ± 9.8 kg), FFM (-1.7 ± 4.8 kg) and REE (-159 ± 191 kcal/24 h) (all p < 0.05). With weight loss, there were no changes in GM and WM. Before and after weight loss, FFM was the main determinant of REE (r² = 0.483 and 0.413; p < 0.05). After weight loss, GM added to the variances

SUBMITTER: Geisler C 

PROVIDER: S-EPMC6893761 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature