In Vivo Characterization of Tick-Borne Encephalitis Virus in Bank Voles (Myodes glareolus).

ABSTRACT: Tick-borne encephalitis is the most important tick-transmitted zoonotic virus infection in Eurasia, causing severe neurological symptoms in humans. The causative agent, the tick-borne encephalitis virus (TBEV), circulates between ticks and a variety of mammalian hosts. To study the interaction between TBEV and one of its suspected reservoir hosts, bank voles of the Western evolutionary lineage were inoculated subcutaneously with either one of eight TBEV strains or the related attenuated Langat virus, and were euthanized after 28 days. In addition, a subset of four strains was characterized in bank voles of the Carpathian linage. Six bank voles were inoculated per strain, and were housed together in groups of three with one uninfected in-contact animal each. Generally, most bank voles did n

SUBMITTER: Michelitsch A 

PROVIDER: S-EPMC6893798 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature