CD38 expression on gluten-specific T cells is a robust marker of gluten re-exposure in coeliac disease.

ABSTRACT:

Background

Increasing efforts are being put into new treatment options for coeliac disease (CeD), a chronic disorder of the small intestine induced by gluten. Interleukin-2 (IL-2) and gluten-specific CD4 + T cells increase in the blood after four hours and six days, respectively, following a gluten challenge in CeD patients. These responses are unique to CeD and are not seen in controls. We aimed to evaluate different markers reflecting a recall response to gluten exposure that may be used to monitor therapy.

Methods

CeD patients on a gluten-free diet underwent a one- (n = 6) or three-day (n = 7) oral gluten challenges. We collected blood samples at several time points between baseline and day 8, and monitored gluten-specific CD4 + T cells for their frequency a

SUBMITTER: Zuhlke S 

PROVIDER: S-EPMC6894002 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature