Biosynthetic metabolomes of cysteinyl-containing immunoresolvents.

ABSTRACT: Resolution of inflammation is an active process regulated by specialized proresolving mediators where we identified 3 new pathways producing allylic epoxide-derived mediators that stimulate regeneration [i.e., peptido-conjugates in tissue regeneration (CTRs)]. Here, using self-limited Escherichia coli peritonitis in mice, we identified endogenous maresin (MaR) CTR (MCTR), protectin (PD) CTR (PCTR), and resolvin CTR in infectious peritoneal exudates and distal spleens, as well as investigated enzymes involved in their biosynthesis. PCTRs were identified to be temporally regulated in peritoneal exudates and spleens. PCTR1 and MCTR1 were each produced by human recombinant leukotriene (LT) C₄ synthase (LTC₄S) and glutathione S-transferases (GSTs) [mic

SUBMITTER: Jouvene CC 

PROVIDER: S-EPMC6894058 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature