Redistribution of EC-SOD resolves bleomycin-induced inflammation <i>via</i> increased apoptosis of recruited alveolar macrophages.

ABSTRACT: A human single nucleotide polymorphism (SNP) in the matrix-binding domain of extracellular superoxide dismutase (EC-SOD), with arginine to glycine substitution at position 213 (R213G), redistributes EC-SOD from the matrix into extracellular fluids. We reported that, following bleomycin (bleo), knockin mice harboring the human R213G SNP (R213G mice) exhibit enhanced resolution of inflammation and protection against fibrosis, compared with wild-type (WT) littermates. In this study, we tested the hypothesis that the EC-SOD R213G SNP promotes resolution via accelerated apoptosis of recruited alveolar macrophage (AM). RNA sequencing and Ingenuity Pathway Analysis 7 d postbleo in recruited AM implicated increased apoptosis and blunted inflammatory responses in the R213G strain exhibiting

SUBMITTER: Allawzi A 

PROVIDER: S-EPMC6894081 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature