Ontology highlight
ABSTRACT:
SUBMITTER: Burgraff NJ
PROVIDER: S-EPMC6894090 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Burgraff Nicholas J NJ Neumueller Suzanne E SE Buchholz Kirstyn J KJ LeClaire John J Hodges Matthew R MR Pan Lawrence L Forster Hubert V HV
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20191031 12
Despite the prevalence of CO<sub>2</sub> retention in human disease, little is known about the adaptive neurobiological effects of chronic hypercapnia. We have recently shown 30-d exposure to increased inspired CO<sub>2</sub> (InCO<sub>2</sub>) leads to a steady-state ventilation that exceeds the level predicted by the sustained acidosis and the acute CO<sub>2</sub>/H<sup>+</sup> chemoreflex, suggesting plasticity within respiratory control centers. Based on data showing brainstem changes in ami ...[more]