Brainstem serotonergic, catecholaminergic, and inflammatory adaptations during chronic hypercapnia in goats.

ABSTRACT: Despite the prevalence of CO₂ retention in human disease, little is known about the adaptive neurobiological effects of chronic hypercapnia. We have recently shown 30-d exposure to increased inspired CO₂ (InCO₂) leads to a steady-state ventilation that exceeds the level predicted by the sustained acidosis and the acute CO₂/H⁺ chemoreflex, suggesting plasticity within respiratory control centers. Based on data showing brainstem changes in aminergic and inflammatory signaling during carotid body denervation-induced hypercapnia, we hypothesized chronic hypercapnia per se will lead to similar changes. We found that: 1) increased InCO₂ increased IL-1β in the medullary raphe (MR), ventral respiratory column, and cune

SUBMITTER: Burgraff NJ 

PROVIDER: S-EPMC6894090 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature