EGFR mutation: novel prognostic factor associated with immune infiltration in lower-grade glioma; an exploratory study.

ABSTRACT: BACKGROUND:Glioma is one of the most common type of primary central nervous system tumors. EGFR mutation, a common alteration occurs in various tumors, is not brought to the forefront in understanding and treating glioma at present. METHODS:In the present study, we demonstrated an immune infiltration related pattern of EGFR mutation in lower-grade glioma. In silico analyses were performed to investigate EGFR mutation and its biological effects and clinical values. GO and GSEA process were used as enrichment analysis. Infiltration levels of specific types of immune cells were estimated at TIMER database. Clinical data of patients were obtained from TCGA and were employed for survival analyses. RESULTS:Here we revealed that EGFR mutation leads to an up-regulation of immune response related p

SUBMITTER: Hao Z 

PROVIDER: S-EPMC6894128 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature